Spectrum of Short Chain Fatty Acids in Chronic Pancreatitis
نویسندگان
چکیده
The aim was to evaluate the metabolic activity of colonic microbiota in patients with chronic pancreatitis (CP) as a marker changes functional state pancreas. Material and methods. 40 (20 men 20 women) aged 35 74 years (50.6 ± 9.4 years) were examined, 26 which had external secretory pancreatic insufficiency (ESPI), confirmed by data elastase test, 14 no ESPI. diagnosis CP established on basis instrumental data. Patients proven ESPI received enzyme replacement therapy (ERT) accordance international Russian recommendations. concentration spectrum short-chain fatty acids evaluated gas-liquid chromatography. control group consisted 22 healthy volunteers (13 women nine 43.4± 6.2 years). Results. As result analysis profiles (SCFAs), significant change content propionic acid revealed without GNP when compared volunteers, differences found between groups CP. These studies indicate decrease certain types colon that produce C3 (propionic acid) and, accordingly, who did not receive ERT. This, apparently, is due violation fermentation individual substrates entering lumen colon. Conclusion. Indicators SCFAs can serve additional tools for detecting pancreas
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ژورنال
عنوان ژورنال: ??????????? ??????????????
سال: 2022
ISSN: ['2307-3586']
DOI: https://doi.org/10.33978/2307-3586-2021-17-39-54-58